利来AG

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奥美拉唑

奥美拉唑用处

Omeprazole(Prilosec)是质子泵遏止剂,可传染打动于消化不良。
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奥美拉唑传染打动

①消化性溃疡出血、吻合口溃疡出血。
②应激形态时并发的急性胃黏膜损害,和非甾体类抗炎药惹起的急性胃黏膜毁伤;
③亦常用于防止重症疾病(如 脑出血 、严峻创伤等)胃手术后防止再出血等;
④全身麻醉或大手术后以及虚弱昏倒患者防止胃酸反流归并吸入性肺炎。
5、胃酸过多患者导致反流性胃炎的酸遏止,以及胃酸过多构成的严峻烧心患者。
6、消化性溃疡胃十二指肠败北者,在医治中也常常会用到奥美拉唑。
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奥美拉唑名称

[ CAS 号 ]:

[ 中文名 ]:
奥美拉唑

[ 英文名 ]:
利来AG omeprazole

[中文别号 ]:

[英文别号 ]:

奥美拉唑生物活性

[ 描述 ]:

Omeprazole(Prilosec)是质子泵遏止剂,可传染打动于消化不良。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬
信号通路 >> 跨膜转运 >> 质子泵
研究范畴 >> 代谢疾病

[参考文献]

[1].

[2].


[相关活性小分子]

巴佛洛霉素A1 | 富马酸沃诺拉赞 | 吡啶硫酮锌 | 兰索拉唑 | 艾普拉唑 | Linaprazan | Soraprazan | 奥美拉唑D3 | Bamaquimast | 埃索美拉唑镁 | 埃索美拉唑镁三水合物 | 诃子林鞣酸 | 吡考拉唑 | SKF96067 | Pumaprazole

奥美拉唑物理化学性质

[ 密度 ]:
利来AG1.4±0.1 g/cm3

[ 沸点 ]:
600.0±60.0 °C at 760 mmHg

[ 熔点 ]:
156ºC

[ 分子式 ]:
C17H19N3O3S

[ 分子量 ]:
345.416

[ 闪点 ]:
利来AG316.7±32.9 °C

[ 切确质量 ]:
345.114716

[ PSA ]:
96.31000

[ LogP ]:
2.17

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.669

[ 储存前提 ]:
2-8°C

[ 不变性 ]:
利来AGStable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark.

[ 水消融性 ]:
利来AGH2O: 0.5 mg/mL

奥美拉唑MSDS

奥美拉唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD9087000
CHEMICAL NAME :
1H-Benzimidazole, 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)met hyl)sulfinyl)-
CAS REGISTRY NUMBER :
73590-58-6
LAST UPDATED :
199806
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C17-H19-N3-O3-S
MOLECULAR WEIGHT :
345.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
800 ug/kg/2D-I
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
30 mg/kg/10W-I
TOXIC EFFECTS :
Blood - eosinophilia Kidney, Ureter, Bladder - interstitial nephritis Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
4 mg/kg/2W-I
TOXIC EFFECTS :
Musculoskeletal - joints Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2210 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Gastrointestinal - hypermotility, diarrhea Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>50 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Gastrointestinal - hypermotility, diarrhea Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
82800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
8320 mg/kg
SEX/DURATION :
female 17-20 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3520 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
TYPE OF TEST :
DNA damage

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 262,73,1991
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奥美拉唑平安动静

[ 符号 ]:

利来AG GHS07

[ 信号词 ]:
Warning

[ 风险声明 ]:
利来AG H315-H319-H335

[ 警示性声明 ]:
利来AG P305 + P351 + P338

[ 小我防护配备 ]:
利来AG dust mask type N95 (US);Eyeshields;Gloves

[ 风险码 (欧洲) ]:
利来AG Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 平安声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
利来AGNONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DD9087000

奥美拉唑上轻贱产物

奥美拉唑制备

【编制一】
3,5-二甲基-2-羟甲基-4-甲氧基吡啶经氯化,生成2-氯甲基-3,5-二甲基-4-甲氧基吡啶。
4-甲氧基1,2-苯二胺和黄原酸钾反映,生成2-巯基-5-甲氧基苯并咪唑,再和上面获得的吡啶衍生物反映,生成2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-5-甲氧基-1H-苯并咪唑,最后在氯仿中,5℃下,用间氯过苯甲酸氧化,获得奥美拉唑。粗品奥美拉唑可用乙腈重结晶。
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奥美拉唑文献

Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole.

Drug Metab. Dispos. 43 , 1408-16, (2015)

The common marmoset (Callithrix jacchus), a small New World monkey, has the potential for use in human drug development due to its evolutionary closeness to humans. Four novel cDNAs, encoding cytochro...

HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics.

Arch. Pharm. Res. 38 , 691-704, (2015)

Although various in vitro assays have been developed to evaluate the cytochrome P450 (CYP)-inducing potential of drug candidates, there is a continuing need for the development of a reliable model in ...

Evaluation of the effect of TM208 on the activity of five cytochrome P450 enzymes using on-line solid-phase extraction HPLC-DAD: a cocktail approach.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 923-924 , 29-36, (2013)

A rapid, simple, and sensitive on-line solid-phase extraction HPLC-DAD method for simultaneous evaluation of the activity of five CYP450 isoforms (CYP1A2, CYP2C19, CYP2D6, CYP2E1 and CYP3A4) in vivo h...


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相关化工产物/化学物质:

相关药品:

保举出产厂家/供应商:

公司名:宝鸡市国康生物科技无限公司

区域:宝鸡市渭滨区

价格:
¥需询单/1kg

联系人:孙司理

产物详情:奥美拉唑


公司名:上海吉至生化科技无限公司

区域:上海市奉贤区

价格:
¥568.0/25g ¥158.0/5g

联系人:王晓燕

产物详情:奥美拉唑


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奥美拉唑供应商


相关化合物

【奥美拉唑】化源网供给奥美拉唑CAS号73590-58-6,奥美拉唑MSDS及其申明、性质、英文名、出产厂家、传染打动/用处、分子量、密度、沸点、熔点、布局式等。CAS号查询奥美拉唑上化源网,专业又轻松。>>电脑版:

标题问题问题:奥美拉唑_MSDS_传染打动_用处_奥美拉唑CAS号【73590-58-6】_化源网 地址:http://sme-solution.com/mip/cas/73590-58-6_591579.html