利来AG


Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.


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L-arginine

L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersL-Arginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.

  • CAS Number: 74-79-3
  • MF: C6H14N4O2
  • MW: 174.201
  • Catalog: NO Synthase
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 367.6±52.0 °C at 760 mmHg
  • Melting Point: 222 °C (dec.)(lit.)
  • Flash Point: 176.1±30.7 °C

Kuwanon A

Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.

  • CAS Number: 62949-77-3
  • MF: C25H24O6
  • MW: 420.45400
  • Catalog: NO Synthase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

L-Arginine hydrochloride

利来AGL-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersArginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.

  • CAS Number: 1119-34-2
  • MF: C6H15ClN4O2
  • MW: 210.662
  • Catalog: NO Synthase
  • Density: 1.42
  • Boiling Point: 409.1ºC at 760 mmHg
  • Melting Point: 226-230 °C(lit.)
  • Flash Point: 201.2ºC

Agmatine sulfate

利来AGAgmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.

  • CAS Number: 2482-00-0
  • MF: C5H16N4O4S
  • MW: 228.270
  • Catalog: Imidazoline Receptor
  • Density: N/A
  • Boiling Point: 281.4ºC at 760 mmHg
  • Melting Point: 234-238 °C(lit.)
  • Flash Point: 124ºC

Piceatannol 3'-O-glucoside

Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC50s of 11.22 µM and 11.06 µM against arginase I and arginase II, respectively.

  • CAS Number: 94356-26-0
  • MF: C20H22O9
  • MW: 406.383
  • Catalog: NO Synthase
  • Density: 1.6±0.1 g/cm3
  • Boiling Point: 721.6±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 390.2±32.9 °C

Asperuloside

Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways[1].

  • CAS Number: 14259-45-1
  • MF: C18H22O11
  • MW: 414.361
  • Catalog: NO Synthase
  • Density: 1.6±0.1 g/cm3
  • Boiling Point: 704.2±60.0 °C at 760 mmHg
  • Melting Point: 131-132°
  • Flash Point: 254.1±26.4 °C

Prim-O-glucosylcimifugin

Prim-O-glucosylcimifugin exerts anti-inflammatory effects through the inhibition of iNOS and COX-2 expression by through regulating JAK2/STAT3 signaling.

  • CAS Number: 80681-45-4
  • MF: C22H28O11
  • MW: 468.451
  • Catalog: NO Synthase
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 736.9±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 255.0±26.4 °C

L-NMMA acetate

利来AGL-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.

  • CAS Number: 53308-83-1
  • MF: C9H20N4O4
  • MW: 248.279
  • Catalog: NO Synthase
  • Density: N/A
  • Boiling Point: 392.7ºC at 760 mmHg
  • Melting Point: 180-190ºC
  • Flash Point: 191.3ºC

L-Canavanine sulfate

L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.

  • CAS Number: 2219-31-0
  • MF: C5H14N4O7S
  • MW: 274.252
  • Catalog: NO Synthase
  • Density: N/A
  • Boiling Point: 574ºC at 760mmHg
  • Melting Point: 160-165 °C (dec.)
  • Flash Point: 300.9ºC

Curvularin

Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2].

  • CAS Number: 10140-70-2
  • MF: C16H20O5
  • MW: 292.32700
  • Catalog: NO Synthase
  • Density: 1.2g/cm3
  • Boiling Point: 557ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 207.9ºC

Syzalterin

Syzalterin is an inhibitor of NO production with an IC50 of 1.87 μg/mL.

  • CAS Number: 94451-48-6
  • MF: C17H14O5
  • MW: 298.290
  • Catalog: NO Synthase
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 569.2±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 215.2±23.6 °C

L-NAME (hydrochloride)

利来AGL-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.

  • CAS Number: 51298-62-5
  • MF: C7H16ClN5O4
  • MW: 269.686
  • Catalog: NO Synthase
  • Density: N/A
  • Boiling Point: 383.5ºC at 760 mmHg
  • Melting Point: 157-161 °C (dec.)
  • Flash Point: 185.8ºC

GW274150

利来AGGW274150 is a novel arginine-competitive, NADPH-dependent iNOS inhibitor that has been identified from a series of acetamide amino acids that have a high selectivity for iNOS vs both eNOS (> 260-fold) and nNOS (> 219-fold) and high bioavailability (> 90%) after oral administration.Target: iNOSin vivo: GW274150 demonstrates a narrow neuroprotective therapeutic window against the toxic actions of 6-OHDA. GW274150 administration leads to a dose-dependent decrease in the number of iNOS-positive cells in the SNc of the 6-OHDA-lesioned animals. The iNOS inhibitor GW274150 fails to produce long-term neuroprotection after its withdrawal in the 6-OHDA-lesioned rat. [1]

  • CAS Number: 210354-22-6
  • MF: C8H17N3O2S
  • MW: 219.30
  • Catalog: NO Synthase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

L-NIO dihydrochloride

利来AGL-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats[2].

  • CAS Number: 159190-44-0
  • MF: C7H17Cl2N3O2
  • MW: 246.135
  • Catalog: NO Synthase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

6-Biopterin

6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor.

  • CAS Number: 22150-76-1
  • MF: C9H11N5O3
  • MW: 237.215
  • Catalog: NO Synthase
  • Density: 1.9±0.1 g/cm3
  • Boiling Point: 563.4±60.0 °C at 760 mmHg
  • Melting Point: >210°C dec.
  • Flash Point: 294.5±32.9 °C

Ginsenoside Rb3

利来AGGinsenoside Rb3 is extracted from steamed Panax notoginseng. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC50 of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.

  • CAS Number: 68406-26-8
  • MF: C53H90O22
  • MW: 1079.269
  • Catalog: NO Synthase
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 1117.1±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 629.4±34.3 °C

s-methyl-l-thiocitrulline

利来AGS-MTC is a selective type I nitric oxide synthase (NOS) inhibitor.

  • CAS Number: 156719-41-4
  • MF: C7H15N3O2S
  • MW: 205.28
  • Catalog: NO Synthase
  • Density: 1.35 g/cm3
  • Boiling Point: 405ºC at 760 mmHg
  • Melting Point: 60ºC
  • Flash Point: 198.7ºC

L-Arg(Me, Me)-OH (asymmetrical)

Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.

  • CAS Number: 30315-93-6
  • MF: C8H18N4O2
  • MW: 202.25400
  • Catalog: NO Synthase
  • Density: 1.239g/cm3
  • Boiling Point: 372.555°C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 179.115°C

Chondroitin sulfate

Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs.

  • CAS Number: 9007-28-7
  • MF: (C14H21NO14S)n
  • MW: 479.368
  • Catalog: Apoptosis
  • Density: 2.0±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Tetrahydrobiopterin

Tetrahydrobiopterin is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.

  • CAS Number: 17528-72-2
  • MF: C9H15N5O3
  • MW: 241.25
  • Catalog: NO Synthase
  • Density: 1.89g/cm3
  • Boiling Point: 506.6ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 260.2ºC

1400W dihydrochloride

1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM.

  • CAS Number: 214358-33-5
  • MF: C10H17Cl2N3
  • MW: 250.168
  • Catalog: NO Synthase
  • Density: N/A
  • Boiling Point: 329ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 152.7ºC

bendazol

Bendazol is a hypotensive drug which can also enhance NO synthase activity in renal glomeruli and collecting tubules.

  • CAS Number: 621-72-7
  • MF: C14H12N2
  • MW: 208.258
  • Catalog: NO Synthase
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 453.5±24.0 °C at 760 mmHg
  • Melting Point: 187ºC
  • Flash Point: 252.1±9.3 °C

α-Caryophyllene

α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC50=15±2 µg/mL). α-Humulene inhibits COX-2 and iNOS expression[1].

  • CAS Number: 6753-98-6
  • MF: C15H24
  • MW: 204.35100
  • Catalog: COX
  • Density: 0.889 g/mL at 20 °C(lit.)
  • Boiling Point: 166-168 °C(lit.)
  • Melting Point: N/A
  • Flash Point: 90°C

AVE-3085

AVE-3085 is a potent endothelial nitric oxide synthase enhancer, used for cardiovascular disease treatment.

  • CAS Number: 450348-85-3
  • MF: C17H13F2NO3
  • MW: 317.287
  • Catalog: NO Synthase
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 420.3±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 208.0±28.7 °C

3',4'-Dihydroxyflavonol

3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries[1].

  • CAS Number: 6068-78-6
  • MF: C15H10O5
  • MW: 270.24
  • Catalog: NO Synthase
  • Density: 1.579g/cm3
  • Boiling Point: 508.9ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 198ºC

Ginsenoside C-K

利来AGGinsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.

  • CAS Number: 39262-14-1
  • MF: C36H62O8
  • MW: 622.873
  • Catalog: COX
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 723.1±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 391.1±32.9 °C

isoquercetin

利来AGQuercetin-3-glucoside is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties.Quercetin-3-glucoside alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway[1].Quercetin-3-glucoside regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Quercetin-3-glucoside has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies[2].

  • CAS Number: 482-35-9
  • MF: C21H20O12
  • MW: 464.376
  • Catalog: NO Synthase
  • Density: 1.9±0.1 g/cm3
  • Boiling Point: 872.6±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 307.5±27.8 °C

L-NIL

L-NIL is a potent and selective inhibitor of inducible NO synthase with IC50s of 3.3 and 92 μM for mouse inducible NO synthase and rat brain constitutive NO synthase, respectively.

  • CAS Number: 53774-63-3
  • MF: C8H17N3O2
  • MW: 187.23900
  • Catalog: NO Synthase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Anemarsaponin B

Anemarsaponin B is a steroidal saponin isolated from the rhizomes of A. asphodeloides (Liliaceae). Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect [1].

  • CAS Number: 139051-27-7
  • MF: C45H74O18
  • MW: 903.058
  • Catalog: COX
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 1023.7±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 572.9±34.3 °C

2-Iminobiotin

2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2].

  • CAS Number: 13395-35-2
  • MF: C10H17N3O2S
  • MW: 243.326
  • Catalog: NO Synthase
  • Density: 1.6±0.1 g/cm3
  • Boiling Point: 477.3±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 242.5±31.5 °C