胰岛素

更新时间:2019-06-15 20:47:25

胰岛素布局式
胰岛素布局式
常用名 胰岛素 英文名 Insulin(cattle)
CAS号 11070-73-8 分子量 5733.49
密度 N/A 沸点 N/A
分子式 C254H377N65O75S6 熔点 N/A
MSDS 美版 闪点 N/A

 胰岛素用处


Insulin cattle 是牛胰脏中胰岛 B-细胞所分泌的一种安排糖代谢的蛋白质激素,是一种多肽。

 胰岛素名称

中文名 胰岛素
英文名 Insulin(cattle)
英文别号 更多

 胰岛素生物活性

描述 Insulin cattle 是牛胰脏中胰岛 B-细胞所分泌的一种安排糖代谢的蛋白质激素,是一种多肽。
相关类别
参考文献

[1].

 胰岛素物理化学性质

分子式 C254H377N65O75S6
分子量 5733.49
外观性状 solution
储存前提 2-8°C
不变性

人胰岛素和猪胰岛素分子布局极其类似,只需B链第30位上的氨基酸不合,猪的是丙氨酸,人的为苏氨酸。基因重组人胰岛素皮下打针后的领受,在体内的失活和分泌均比纯化猪胰岛素快,对高血糖的节制传染打动比动物胰岛素火速,对动物原性胰岛素有过敏反映的患者,用重组人胰岛素则反映优良。

水消融性 acidified water, pH 2.0: 2 mg/mL
算计化学

利来AG1.疏水参数算计参考值(XlogP):-12.8

2.氢键供体数量:76

3.氢键受体数量:87

4.可扭转化学键数量:176

利来AG5.互变异构体数量:1001

利来AG6.拓扑分子极性概况积2410

7.重原子数量:400

8.概况电荷:0

利来AG9.复杂度:14400

10.同位素原子数量:0

11.确定原子立构核心数量:49

12.不确定原子立构核心数量:0

13.确定化学键立构核心数量:0

14.不确定化学键立构核心数量:0

15.共价键单元数量:1

 胰岛素平安动静

小我防护配备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
平安声明 (欧洲) 22-24/25
危险品运输编码 NONH for all modes of transport
WGK德国 3
RTECS号 NM8900250

 胰岛素制备

从大肠杆菌发生胰岛素有两个路子,一是分袂在大肠杆菌中合成A链和B链,再在体外用化学编制连接两条肽链构成胰岛素;另一种编制是出产胰岛素原(Proinsulin),即胰岛素前体,再用酶加工成胰岛素。用大肠杆菌出产的人胰岛素,每L发酵液可收获胰岛素40mg。

 胰岛素文献39

更多文献
[6]-Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKα2-Mediated AS160-Rab5 Pathway and AMPK-Mediated Insulin Sensitizing Effects.

J. Cell. Biochem. 116 , 1401-10, (2015)

[6]-Gingerol has been used to control diabetes and dyslipidemia; however, its metabolic role is poorly understood. In this study, [6]-gingerol increased adenosine monophosphate (AMP)-activated protein...

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells.

利来AGGenes Dev. 29 , 1298-315, (2015)

Mutant p53 impacts the expression of numerous genes at the level of transcription to mediate oncogenesis. We identified vascular endothelial growth factor receptor 2 (VEGFR2), the primary functional V...

Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells.

Cancer Sci. 99(8) , 1584-8, (2008)

The growth of LNCaP, a human prostate adenocarcinoma cell line, and MCF-7, a human breast adenocarcinoma cell line, is initially hormone dependent. We previously demonstrated that LNrho0-8 and MCFrho0...

 胰岛素英文别号

(4S)-4-[[2-[[(1R,4S,7S,10S,13S,16S,19S,22S,25S,28R,33R,36S,39S,42S,45S,48S,51S,54S,57S,60S,63S,69R,74R,77S,80S,83S,90R)-90-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[(2-aminoacetyl)amino]-3-methyl-pentanoyl]amino]-3-methyl-butanoyl]amino]-5-hydroxy-5-oxo-pentanoyl]amino]-5-oxo-pentanoyl]amino]-69-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-amino-3-phenyl-propanoyl]amino]-3-methyl-butanoyl]amino]-4-oxo-butanoyl]amino]-5-oxo-pentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]amino]-4-methyl-pentanoyl]amino]-28-[[(1S)-3-amino-1-carboxy-3-oxo-propyl]carbamoyl]-22-(2-amino-2-oxo-ethyl)-13-(3-amino-3-oxo-propyl)-19,51-bis(2-carboxyethyl)-4,63,80-tris(hydroxymethyl)-10,25,42-tris[(4-hydroxyphenyl)methyl]-60-(3H-imidazol-4-ylmethyl)-7,16,39,45,57-pentaisobutyl-36,54,83-triisopropyl-48,77-dimethyl-2,5,8,11,14,17,20,23,26,35,38,41,44,47,50,53,56,59,62,65,68,75,78,81,84,91-hexacosaoxo-30,31,71,72,87,88-hexathia-3,6,9,12,15,18,21,24,27,34,37,40,43,46,49,52,55,58,61,64,67,76,79,82,85,92-hexacosazabicyclo[72.11.7]dononacontane-33-carbonyl]amino]acetyl]amino]-5-[[(1S)-1-[[2-[[(1S)-2-[[(1S)-2-[[(1S)-2-[[(1S,2R)-1-[(2S)-2-[[(1S)-5-amino-1-[[(1S)-2-hydroxy-1-methyl-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]pyrrolidine-1-carbonyl]-2-hydroxy-propyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-benzyl-2-oxo-ethyl]amino]-1-benzyl-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-5-oxo-pentanoic acid
保举出产厂家/供应商:我要呈现这里



利来AG查看所有供应商和价格请点击:

胰岛素出产厂家


参考价格:$72/10mg

更多胰岛素价格


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